IIT Bombay Study Uncovers Why Some Antibiotics Harm Liver More

• IIT Bombay study, led by Professor Ashutosh Kumar, reveals why certain antibiotics cause more liver damage, challenging old theories.
• Liver damage is linked to *how* and *where* a drug binds to liver cell membranes, not just its potency.
• Comparison of Teicoplanin and Oritavancin showed Teicoplanin, which adheres to the cell surface, is more fatal than Oritavancin, which penetrates deep.
• Experiments on mice confirmed Teicoplanin significantly increased liver enzymes and damage, while Oritavancin had minimal effects.
• This discovery could revolutionize drug development, allowing scientists to predict liver safety and design safer drugs that minimally interfere with healthy cells.