Why Your 40s Feel So Exhausting: Science Reveals Life’s Most Draining Decade

• Scientific discussions suggest the 40s may be the most exhausting decade due to biological aging, professional, financial, and family responsibilities.
• Fatigue in the 40s has a biological basis, including declining cellular energy production, reduced basal metabolic rate (BMR), and hormonal shifts.
• Midlife often brings peak career and family responsibilities, with many becoming the "sandwich generation" supporting both children and aging parents.
• The brain and heart face increased stress from hormonal changes and lifestyle factors, impacting mental stamina and cardiovascular health.
• The 60s can bring more predictable energy levels as life pressures reduce, self-care increases, and mitochondria adapt with healthy habits.