IIT Bombay Breakthrough: New Method Boosts CAR T-Cell Cancer Therapy Effectiveness

• IIT Bombay researchers developed an advanced method to recover immune cells for T-cell based cancer therapy, enhancing treatment effectiveness.
• The new technique focuses on safely and effectively recovering lab-grown T-cells, a critical step for therapies like CAR T-cell treatment.
• Professor Prakriti Tayalia highlighted cell recovery as a major challenge, emphasizing the need for sufficient healthy cells for testing and therapy.
• Researchers used electrospun scaffolds made of polycaprolactone to mimic the body's natural environment for growing Jurkat T-cells.
• The study found that using the milder enzyme 'Accutase' for cell recovery significantly improved survival rates and maintained healthy T-cell behavior compared to trypsin.