IIT Jodhpur's Breakthrough: Human Protein Prevents Dangerous Biofilms, Revolutionizing Treatment

• IIT Jodhpur scientists discovered a human protein, β2-microglobulin, prevents dangerous bacterial biofilm formation.
• Biofilms are a major cause of chronic infections and Antimicrobial Resistance (AMR), making bacteria up to 1000 times more antibiotic-resistant.
• The protein inhibits Curli production in E. coli, weakening the bacteria's protective structure without killing them, reducing resistance risk.
• This discovery offers a new therapeutic pathway, distinct from traditional antibiotics, by preventing biofilm formation at an early stage.
• The research, published in PNAS, opens doors for developing new drugs to combat chronic infections and implant-related complications.