Gut Molecule TMA Blocks IRAK4, Improves Insulin Sensitivity

• Gut molecule TMA blocks immune protein IRAK4, reducing inflammation and improving insulin sensitivity.
• TMA, a metabolite created by gut microbes from dietary choline, counteracts damage from high-fat diets and protects mice from sepsis.
• The discovery suggests new diabetes therapies by targeting IRAK4, which is already a known drug target.
• Research highlights how gut microbes and nutrition can work together to support metabolic health and fight inflammation.

Why It Matters: A gut molecule discovery could lead to new diabetes treatments.