The findings are significant because about half of people with obesity stop using so-called GLP-1 drugs within a year
India
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Moneycontrol08-01-2026, 07:22

Obesity Drugs: Weight Regain Faster Than Diet After Stopping, Study Finds

  • Patients regain weight almost four times faster after stopping obesity drugs compared to coming off a diet.
  • Weight returns to original levels in less than two years after stopping treatment, with an average gain of 0.4 kg/month.
  • About half of GLP-1 drug users stop within a year, indicating drugs alone may not ensure long-term weight control.
  • Stopping drugs also reverses improvements in cardiovascular and metabolic markers like cholesterol and blood pressure.
  • Behavioral programs (diet, exercise) lead to slower weight regain, emphasizing sustained lifestyle changes.

Why It Matters: Stopping obesity drugs leads to rapid weight regain and loss of health benefits, unlike sustained behavioral changes.

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